Diastolic Function in Heart Failure

Diastolic Function in Heart Failure

Heart failure has reached epidemic proportions, and diastolic heart failure or heart failure with preserved ejection fraction (HFpEF) constitutes about 50% of all heart failure admissions. Long-term prognosis of both reduced ejection fraction heart failure and HFpEF are similarly dismal. No pharmacologic agent has been developed that actually treats or repairs the physiologic deficit(s) respons...

Left atrial function in diastolic heart failure.

BACKGROUND Abnormalities in left ventricular (LV) structure and function occur in patients with diastolic heart failure (DHF). The reasons for the transition from asymptomatic dysfunction to heart failure need better definition, including noninvasive measurements that can detect the transition. METHODS AND RESULTS In 64 patients undergoing right heart catheterization, simultaneous echocardiog...

Personalized Computer Simulation of Diastolic Function in Heart Failure

The search for a parameter representing left ventricular relaxation from non-invasive and invasive diagnostic tools has been extensive, since heart failure (HF) with preserved ejection fraction (HF-pEF) is a global health problem. We explore here the feasibility using patient-specific cardiac computer modeling to capture diastolic parameters in patients suffering from different degrees of systo...

The role of left atrial function in diastolic heart failure.

New heart failure affects 500 000 Americans yearly. Nearly 50% of these patients have a normal left ventricular ejection fraction (LVEF) or so-called diastolic heart failure (DHF). New onset symptomatic DHF is a lethal disease with a 5-year mortality that approaches 50%.1 EchoDoppler techniques use LV filling patterns and tissue Doppler imaging of the mitral annulus to help identify and classif...

Diastolic Heart Failure